Word: marrowed
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...destroying instant that all my adult life I had believed in God and this knowledge was a vision of God. Fright entered the very marrow of my bones. Surrounded, swamped, confused, all but destroyed, adrift in the universal intolerance, mouth open, screaming bepissed and beshitten, I knew my maker and fell down...
...grass and some day to live normally in the world. For this hope David, 12, and his family took the ultimate gamble: they traded the safety of a germ-free plastic bubble at Houston's Texas Children's Hospital for the slim chance that a bone-marrow transplant would allow the immunologically defenseless boy to live freely. Last week they lost their gamble, and his death was felt across the country...
...only hope for a cure was a transplant of bone marrow, which could provide the body with a rapidly multiplying source of defender cells to ward off disease. Such transplants were once possible only if a genetically matched donor, generally a sibling, could be found. Sadly, David's older sister's cell type did not match his. In the past few years, however, new technology has made it possible to transplant imperfectly matched marrow, making obsolete the isolation approach to David's illness. "There will be no more bubbles," said Dr. William Shearer...
...waiting arms. But that brief reunion was clouded by worry: a persistent fever, diarrhea and vomiting had made it necessary for doctors to treat him outside the bubble. The symptoms, doctors feared, were signs of the often fatal graft vs. host disease, which occurs when cells from donated marrow attack the recipient's body. During the next 15 days, David developed severe ulceration of his digestive tract and a dangerous accumulation of fluid in his lungs and around his heart. The exhausted child finally died of cardiac failure. Shearer recalled that at the end David asked...
DIED. David, 12, the longest survivor of severe combined immunodeficiency; 15 days after being released from a lifetime of isolation inside a plastic "bubble"; of complications after a bone-marrow transplant; in Houston (see MEDICINE...