Word: marrows
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...payoff from it may come a bit sooner. In that experiment, a team of scienlists led by Martin Cline and Winston Salser isolated genes that help produce an enzyme resistant to methotrexate, a drug used to treat cancer. The researchers added the genes to cell cultures of mouse bone marrow. The cells that picked up the foreign material, along with cells that had been incubated with genes that do not confer resistance, were then injected into mice whose own bone marrow had been destroyed. To see if the drug-resistance genes were working, the animals were given methotrexate. Tests after...
...U.C.L.A. findings may eventually help patients undergoing cancer chemotherapy. Methotrexate, used to treat leukemia and other cancers, is like most antitumor drugs: potent but harsh. It indiscriminately destroys rapidly proliferating cells, malignant and healthy alike. Among the healthy ones are those of bone marrow, which produce blood cells. The damage that methotrexate does to bone marrow effectively limits how much of it can be given to patients. Making the cells resistant to the drug's assault might give patients the ability to withstand more intensive therapy...
Researchers also speculate that doctors might use the technique to correct blood diseases that result from defects in single genes, including sickle-cell anemia and thalassemia. The therapeutic gene could be transferred into bone marrow cells along with a gene for drug resistance. Exposure to the drug would kill off marrow that produces defective blood cells and allow a population of "cured" cells to take over...
...create human hybridomas. They took spleen cells from victims of Hodgkin's disease, a form of cancer in which the spleen is usually removed during treatment. The cells had already been exposed to the chemical dinitrochlorobenzene and were making antibodies. These cells were then fused with cancerous bone-marrow cells, yielding hybrid cells that could churn out the antibody...
DIED. Teddy DeVita, 17, whose struggle to conquer a rare bone marrow disease in an 8-ft. by 9-ft., germ-free isolation room at the National Cancer Institute won him wide attention as the courageous "boy in the glass cage"; of complications from repeated blood transfusions; in Bethesda, Md. Teddy was nine when he developed aplastic anemia, which destroys the body's ability to fight off any infection. His life in his sterile sanctuary, portrayed by John Travolta in a 1976 TV film, was poignant: he sometimes threatened to walk out to virtually certain death, but mostly...