Word: marrows
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...Rockefeller University in 1950. Good observed lhat patients with different types of tumors suffered from different types of infections. Those with Hodgkin's disease, a cancer of the lymphoid system, were particularly susceptible to TB, fungus and viral infections; those with multiple myelomas, or cancers of the bone marrow, were vulnerable to such bacterial infections as streptococcus and pneumococcus. Subsequent observation and experiments at the University of Minnesota convinced Good that there were not one but two basic immune responses. One, controlled by the thymus, was responsible for delayed hypersensitivity, or certain types of allergic responses, and the rejection...
...Good and his group in the mid-'60s, the "two component" theory became the foundation of modern immunology, and led to new experiments and ways to understand the phenomenon of immune response. It also led to another of Good's contributions ?the first successful use of bone-marrow transplants to correct immunodeficiency disease...
...Doctors had experimented with bone-marrow transplants in the mid-'50s, primarily to combat leukemia. But their efforts proved generally unsuccessful. Immunologically sound bone marrow contained cells that recognized the recipient of this gift as "foreign." The new cells, in a phenomenon known as "graft v. host" reaction, thus rejected the host, producing lymphocytes capable of reacting with and destroying his tissue. In fact, the reaction, combined with infection and other factors, could prove fatal to the recipient whose immune system was either weak or absent...
Legacy. Good tried a different approach with five-month-old David Camp, who was suffering from hereditary immunodeficiency disease, which had already killed twelve infants on the maternal side of his family. Thinking back to work that he himself had done in 1956, Good remembered that mice given bone marrow from donors whose cells were genetically similar suffered from graft-v.-host reaction but never died from it. He reasoned that David, too, would survive if a good tissue match could be found...
...contended that the Rosenbergs lived an existence governed solely by their Communism, and that this was somehow disgusting. But even though the critics' background held traces of the Rosenbergs' Bronx roots, they weren't concerned at all with the process by which the couple's beliefs invaded the very marrow of their lives. The spies made adult choices, the wrong ones; to know they are wrong said Warshow, is all that counts. Fiedler at least thought revocation of the death sentence in order...