Word: marrows
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Anderson concedes that the historic gene therapy practiced on Ashi did not produce a cure, because the T cells made by her bone marrow still lack their own functional ADA gene. "Nevertheless," he insists, "Ashi does provide the proof of principle that if you put a correct gene into enough cells in a patient, you will correct the disease...
...doing everything you can to protect your children? What if, God forbid, your daughter developed leukemia and needed a bone-marrow transplant? What if neither you nor your spouse could offer a close enough match to donate marrow? If you'd had the foresight to preserve some critical blood cells found in the umbilical cord and placenta that nourished your other children in the womb, you might be able to save your daughter's life...
First, it helps to understand that bone-marrow transplants are the most unforgiving of all transplant operations, requiring closer matches in tissue types between donors and recipients than for, say, hearts or kidneys. Because the immune system comes from the marrow, a transplant of that reddish pulp is, in effect, an immune-system transplant. There's the usual possibility that the body may reject the graft as "foreign." Then there's the almost surreal danger that the transplanted immune system will attack and kill its host...
...important stem cells that can generate a new immune system. Even better, these cells are, as doctors put it, "naive," making them less likely to attack their new host. As a result, a cord-blood transplant doesn't have to match a recipient quite so closely as a bone-marrow transplant. This experimental treatment could prove especially helpful to African-American patients and other minorities whose greater genetic diversity often means they have trouble finding a good bone-marrow match...
...award will take on added significance for Stauffer since Jan. 10 will mark the one-year anniversary of the death of her brother Matt from leukemia. Stauffer twice donated bone marrow to Matt and took the 1997 fall semester off to spend time with...