Word: marrows
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...armpits and other cavities turning almost black. Excruciating blisters appear on the neck, chest and thighs, causing patches of skin to fall off. Large lesions discolor the genital area. For some, the blisters and the terror eventually fade, although they may be plagued by side effects like bone-marrow or gastrointestinal problems for years to come. Others perish quickly, the silenced victims of a silent killer...
...interleukin-7 and interleukin-8," says Immunologist Lloyd Old, of the Memorial Sloan-Kettering Cancer Center in Manhattan, "and one can expect that we will go on from there." Scientists have so far discovered at least five different colony-stimulating factors, which cause cells in the bone marrow to mature and differentiate into red and white blood cells. Each of the players seems to have a vital, if sometimes overlapping, role...
...bioengineering techniques, medical researchers have begun to mass- produce these substances and use them, sometimes in combined "cocktails," to boost the immune system against specific diseases. In clinical trials at Boston's New England Deaconess Hospital, Dr. Jerome Groopman has found that granulocyte-macrophage colony-stimulating factor reverses bone-marrow failure and boosts white-cell counts in AIDS patients. Gamma interferon seems to remedy the defective functioning of monocytes and macrophages in a wide variety of diseases. Alpha interferon has been particularly effective against two types of leukemia and non-Hodgkin's lymphoma, a cancer of the lymph system. Says...
...which both B cells and T cells are lacking. The most famous SCID victim, a Texas boy named David, lived for twelve years in a germ-free bubble while doctors searched in vain for a cure for his disease. He died in 1984, four months after receiving a bone-marrow transplant that doctors hoped would supply his missing immune cells...
Three-year old Chrisha Froio, from Rehoboth, Massachusetts, had a particularly difficult move. Chrisha, who received a bone marrow transplant from her father almost four weeks ago, left her sterile room for the first time since the surgery...