Word: marsilid
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Dates: during 1950-1959
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...another potent drug. It is used not only in psychiatry, but also for cancer patients when they know the end is near, and in some unrelated disorders where its apparent value is not fully understood, e.g., angina pectoris and rheumatoid arthritis. Hoffmann-La Roche Inc. (which markets iproniazid as Marsilid) and rival manufacturers have brought out drugs that are close chemical kin to iproniazid but with fewer drawbacks...
...remarkable new anti-depression drug introduced last year (TIME, Dec. 16), was sparked last week by the death of a San Francisco woman whose physician prescribed it. A coroner's jury ruled that her death (of hepatitis) was directly due to the drug, which is trade-named Marsilid by its maker, Hoffman-La Roche Inc. of Nutley. N.J. In January and February the drug house cut the recommended daily dosage for moderately depressed patients from 150 milligrams to a maximum of 50. It tried to notify most practicing U.S. physicians, but the information never reached the woman...
Medical researchers reported last week that they have found a sort of untran-quilizer-a drug that shows promise in treating mental patients suffering from depression. It is no new chemical, but iproniazid (trade name: Marsilid), first cousin of isoniazid and a veteran of the 1951 campaign against tuberculosis. When it was given to TB patients at New York City's Sea View Hospital, they became happy, ate ravenously, gained weight and started dancing in the wards (TIME, March 3, 1952). Iproniazid was soon retired from widespread use because it produced undesirable side effects, such as dizziness, constipation, difficulty...
...hydrazide of isonicotinic acid, marketed under such names as Rimifon, Nydrazid, Pyricidin, Dinacrin. A related drug is trade-named Marsilid...
...Marsilid, one of the isoniazed* drugs now being widely tested against T.B., may be useful for a lot of other things, three New York City doctors reported in London. They found that it relieves pain, and can be used as a substitute for narcotics in some advanced cases of cancer. It is also being tried on narcotic addicts to ease withdrawal symptoms...