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The letter was devastating enough, but Mathias knew it was a lie. The truth was that the trial had been suspended out of a growing concern among McGee's supervisors that it may have been doing more harm than good. So after agonizing for days about what to do, she...

Author: /time Magazine | Title: At Your Own Risk | 4/22/2002 | See Source »

In the Oklahoma case, it may have been a nobler motive that tripped up McGee. "McGee is a good surgeon and a decent man," maintains his whistle-blowing research nurse, Mathias. "But he became a biased investigator. He thought he had found the cure for cancer. He really wasn't...

Author: /time Magazine | Title: At Your Own Risk | 4/22/2002 | See Source »

Mathias reported substantial protocol violations to Plunket and told Dr. Harold Brooks, dean of the university's College of Medicine in Tulsa, as well. They finally agreed to hire an outside consulting firm to audit the experiment. The finding: deficiencies "so severe that it is beyond the scope of this...

Author: /time Magazine | Title: At Your Own Risk | 4/22/2002 | See Source »

That's when Mathias wrote her whistle-blowing letter. On the basis of its investigation, the OHRP shut down all federally funded human research at the university. The university, meanwhile, did its own digging and came to the same conclusions. It disbanded the Tulsa IRB, suspended and later fired McGee...

Author: /time Magazine | Title: At Your Own Risk | 4/22/2002 | See Source »

But the U.S. can't afford to wait for every research institution to react to its own lapses. That's the impetus for a sweeping overhaul of the OHRP, designed by director Greg Koski--with advice from a newly motivated Johns Hopkins--to make the agency more aggressive in protecting...

Author: /time Magazine | Title: At Your Own Risk | 4/22/2002 | See Source »

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