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Traditionally, new vaccines are tested in mice, rabbits or, in the case of AIDS, monkeys. But animal testing is time-consuming, expensive, and controversial. The biggest bugaboo of all is translation. No matter how well an experimental vaccine works in animals, the leap to humans is riddled with uncertainty and unforeseeable complications. Last year's collapse of a late-stage AIDS vaccine trial involving thousands of volunteers is a case in point. The experimental vaccine used in the STEP study, co-sponsored by the National Institutes of Health and the vaccine's creator, pharmaceutical giant Merck, looked promising in monkeys...

Author: /time Magazine | Title: Putting Immunity in a Test Tube | 3/27/2008 | See Source »

...Roger Federer wield state-of-the-art equipment that may be subtly different from what their opponents use, but it's not better (nor particularly high-priced). In F1, however, some cars are indisputably better than others. Recently, those superior cars have belonged to Ferrari and McLaren, and no matter how good a driver you may have been, if you weren't with one of those teams you were not going to win a world championship. Seven drivers representing five teams didn't score a single point in last year's championship, meaning they failed to finish eighth or better...

Author: /time Magazine | Title: Showing Their Metal | 3/27/2008 | See Source »

...Probiotics Revolution. In the digestive tract, the bacteria help regulate and restore peristalsis, the rhythmic motion of the intestine that pushes digested food through. There's a reason one of the bugs has the word regularis as its second name, and this intestinal toning is it. "Doesn't matter if you are constipated or the opposite," Huffnagle says. "These bacteria can help make you, um, regular...

Author: /time Magazine | Title: Eat Your Germs | 3/27/2008 | See Source »

Ultimately, it doesn't matter. It's made clear from the start that Chris and Roza's relationship will not last - and their separation resonates with the sorrow of what could have been. That regret keeps Roza in Chris' life, but only as a character in his story. Memories aren't important, Roza once told him. But in the end, they are all he has left...

Author: /time Magazine | Title: Louis de Bernières: Going Nowhere | 3/26/2008 | See Source »

...mail to find my messages unanswered and a death notification from a West Point distro list in my inbox. The dead in Afghanistan don't seem to inspire the keeping of lists the same way that those in Iraq do, but even if they did it wouldn't matter; he could only be number...

Author: /time Magazine | Title: The Real Meaning of 4,000 Dead | 3/26/2008 | See Source »

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