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...which mops up harmful triglycerides in the blood and boosts levels of "good" cholesterol. But all of the volunteers either already suffered from heart disease, or had two or more major risk factors for heart problems - including cigarette smoking, family history and high cholesterol - in addition to diabetes. That may have pushed their diabetes too far along to allow them to see any benefit from the drugs. "This may be too late a state to expect major benefits from the medications," says Ganda...
Another reason these patients showed no significant heart benefits, he says, may be that most of them never needed the fibrate to begin with. About two-thirds of the patients in the trial already had triglyceride levels below those at which doctors would normally prescribe the drug, which skewed the study results toward the negative side...
That's a pattern that many diabetes experts expect to emerge more robustly as researchers dig deeper into the data. It's possible, for instance, that younger, newly diagnosed patients with diabetes may actually benefit from aggressively lowering their blood pressure, cholesterol and blood sugar levels - a trend that may have been lost in the noise of the current studies, which included patients who were up to 79 years old. "I tend to be far more tuned in to getting normal targets in my younger patients," says Dr. Daniel Einhorn, medical director of the Scripps Whittier Diabetes Institute...
...primary lesson that clinicians can take away from the new findings is that the blind push to lower all risk factors such as blood pressure or cholesterol isn't necessarily healthy, says Dr. Christopher Saudek, director of the diabetes center at Johns Hopkins University. That may even mean resisting the commonsense urge to reduce these measures to recommended or normal range in diabetics patients. "To me, it's a matter of having reasonable and patient-oriented individual targets," he says, "rather than trying to push and push and push just to get lower and lower glucose or blood pressure...
Smith, 22, allegedly gave her Harvard ID card—which provides electronic swipe access—to the three New York men involved in the shooting of 21-year-old Cambridge resident Justin Cosby in Kirkland House last May. Smith, then a Lowell House senior, was the long-time girlfriend of Jabrai J. Copney, 20, one of the three men connected to the incident...