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...weight when they noticed that lab mice lacking a certain protein had more of the bugs than other animals and were about 15% heavier. These mice also had a higher level of inflammation, which the authors explain in their paper published online Thursday in Science Express is what may account for the extra weight. Inflammatory signaling can promote a condition called metabolic syndrome, which causes weight gain, high blood pressure and high cholesterol levels and a higher risk for developing diabetes and heart disease...
...some of those species are missing, or that some are in greater abundance," he says. The net effect, however, is that in the absence of TLR5, the community of microbes changes and, as Gewirtz says, "when the intestinal bacteria is changed, the host response changes with them, and that may predispose you to a variety of diseases of which obesity and metabolic syndrome are perhaps the most mild." (See the 10 worst fast food meals...
...Wednesday in Nature, an international group of scientists generated the most comprehensive genetic map to date of human gut microbes, using 124 human fecal samples, which gives scientists just the critical window they need to figure out which species of bugs tend to reside in our intestines and which may contribute to weight gain. (See how to prevent illness...
While Gewirtz's latest findings are limited to mice, experts believe they may be just as applicable to humans; previous work on gut microbiota has found that obese individuals tend to have a makeup of pathogens in their intestines different from that of people who are of normal weight. "Our results suggest that the tendency to eat more may not only be driven by the fact that food is cheaper and more available, but by a change in the bacteria in the intestines," he says. "People may be eating too much because their appetite is stronger...
Researchers at Harvard Medical School have made a landmark discovery in cancer genomics that may permanently shift the way cancer is currently diagnosed...