Word: mazes
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...active in our lives every day, regulating how various cells in our bodies behave. In the brain this can be especially powerful. Any significant experience triggers changes in brain genes that produce proteins - those necessary to help memories form, for example. But, says the study's lead author, Ian Maze, a doctoral student at Mount Sinai School of Medicine, "when you give an animal a single dose of cocaine, you start to have genes aberrantly turn on and off in a strange pattern that we are still trying to figure...
...Maze's research focused on a particular protein called G9a that is associated with cocaine-related changes in the nucleus accumbens, a brain region essential for the experience of desire, pleasure and drive. The role of the protein appears to be to shut down genes that shouldn't be on. One-time use of cocaine increases levels of G9a. But repeated use works the other way, suppressing the protein and reducing its overall control of gene activation. Without enough G9a, those overactive genes cause brain cells to generate more dendritic spines, which are the parts of cells that make connections...
...incident is the latest step in a decades-old dance involving Laos' communists, the Hmong and the U.S. In the lead-up to the Vietnam War, North Vietnam carved a maze of transportation routes through the jungles of Laos, creating a crucial supply link later known as the Ho Chi Minh Trail. Laos was in the middle of a civil war between the Royal Lao government and the communist Pathet Lao. Seeking to disrupt the North's supply routes, the Americans enlisted the help of the Royal Lao government's highest-ranking Hmong leader, Vang Pao. He welcomed American guns...
London's West End is one of the world's great shopping districts. Its two main arteries, Regent and Oxford streets, and its capillary-like maze of side streets, are crammed with some of the biggest and trendiest names in retailing. But shopping in the West End can be downright exhausting: sidewalks heaving with humanity; the constant din of noise; traffic fumes; foul weather...
...Tsui's medley of Michael Jackson hits has been viewed more than 2.4 million times - but he hasn't made any money yet from that music video or any of the others he and a classmate have produced. Like many viral sensations, he is suddenly trying to navigate a maze of advertising offers, promotional deals and legal issues in the hopes of making a (typically small) fortune from Internet fame. (Watch Sam Tsui explain his YouTube success...