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Currently, Guilford Pharmaceuticals in Baltimore, Md., and Amgen in Thousand Oaks, Calif., are collaborating on a synthetic neurotrophic compound that can be taken orally and then travels to the brain, where it bonds with proteins in dopamine neurons. The tricky part is that most trophic molecules are too big to move across the miniscule blood vessels in the brain, so Guilford and Amgen are working on a smaller one that can get where it needs to go. The progress so far is promising. "We're in Phase 2 human trials now," says Dr. Craig Smith, president of Guilford. "Although...
Like California's Silicon Valley and Massachusetts' Route 128, Montgomery County, Md., has been transformed in the past decade from a sleepy suburb into a bustling scientific Mecca. The 15-mile stretch of Interstate 270 that runs from Bethesda to Gaithersburg now houses one of the world's largest and smartest collections of genomic firms. The chief draw is the NIH, which dispenses $14 billion a year in research grants. But there are other attractions--proximity to Johns Hopkins, a start-up-friendly local government, an abundance of office space; and most of all, a critical mass of like-minded...
...have been around. And it will continue while Israel exists as a Jewish state and controls holy sites of two other major faiths. Arabs, both Christian and Muslim, will rebel to get back these sites. What ever happened to the lesson of sharing? JAMIL BATCHA, Age 16 Hunt Valley, Md...
...cholesterol level has never been disclosed; doctors have said only that it is being treated. His estimated 40% "ejection fraction," a measure of how efficiently his heart is pumping blood, suggests that Cheney's heart is "moderately impaired," according to Dr. Roger Blumenthal of Johns Hopkins Hospital in Baltimore, Md., and it places him at somewhat higher risk for another heart attack...
...support to teachers in everything from reading and math to violence prevention. The team approach gives schools a critical mass of input from the volunteers. It also gives the volunteers something priceless: a chance to make friends with other older people engaged in the same worthwhile task. The Baltimore, Md., chapter, now in its second year in six schools, is monitoring the educational benefits for students and the mental, physical and social effects on the volunteers. Reading scores have gone up at participating schools, and retention among the 150 volunteers is 97%, better than the rate for paid school staff...