Word: melanoma
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Dates: during 1970-1979
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...says, a small pigmented lesion had appeared above Roosevelt's left eye. In following years it seems to have enlarged and grown downward into the eyebrow. But after 1943 the lesion was gone. That leads Goldsmith to believe that the lesion was a sign of malignant melanoma-a form of skin cancer that can spread to other organs-and that it was surgically removed in 1943. He also suspects that when Lahey was called to the White House in March 1944, the physician found that the cancer had metastasized-perhaps to the gastrointestinal tract; several sources confirm that Roosevelt...
Wick said that the first step is to identify a chemical trait unique to the cancerous cells such as the presence of L-dopa. Both melanoma and neuroblastoma are jet-black tumors due to the pigment-producing abilities of their host cells, he said...
...dopa is the starting material for the synthesis of melanin, a pigment commonly found in skin cells affected by melanoma, a form of skin cancer. In the brain cells affected by neuroblastoma, another form of cancer, L-dopa serves as a starting material for the manufacture of norepinephrine, a chemical signal in the nervous system...
Experiments with isolated melanoma cells and with melanoma cells inside mice bore out these predictions...
...rate, it could ultimately deplete the three-mile-thick ozone layer by as much as 7%. Public health authorities predict that the subsequent increase in the amount of ultraviolet light reaching the earth would raise by about 200 the number of Americans afflicted annually by malignant melanoma, a form of skin cancer that now strikes an estimated 8,400 and kills some 2,700 each year. The ozone loss would bring an increase in other forms of skin cancer as well...