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...side effects, including uncontrollable vomiting and debilitating migraine headaches. The basement lab had been completely redecorated--walls had been torn out, a giant fish tank installed--and yet Dawanna could barely muster the strength to go inside. She was literally shaking. She says that as a result of the melanoma trial, she has lost all faith in the medical profession. She no longer takes drugs for her melanoma and hasn't been to a doctor in more than a year. 'I'm not prepared to be let down again,' she told me. But I also spoke to a few patients...

Author: /time Magazine | Title: Reporters' Notebook | 4/22/2002 | See Source »

ANDREW GOLDSTEIN, a staff writer, went to Tulsa, Okla., for this week's cover story and interviewed terminally ill patients taking an experimental melanoma vaccine found to have been manufactured, stored and tested improperly...

Author: /time Magazine | Title: Reporters' Notebook | 4/22/2002 | See Source »

April showers may well bring May flowers, but this year April sunshine has been bringing out scores of Harvard sunbathers. Even the most dour students have found themselves tempted outside, content to forget work for a few hours and dedicate themselves to the wholesome pursuit of melanoma. After all, there could be few places more beautiful to lie outside than in the middle of Harvard Yard—except when it is barricaded off for fertilization—or down on the grassy banks of the Charles...

Author: By Anthony S.A. Freinberg, | Title: Ivory Towers of Concrete | 4/11/2002 | See Source »

...except in a few rare types of malignancy. And a cancer cell, unlike an invading pathogen, isn't wholly foreign to the body. Nevertheless, researchers are learning that the immune system can even be trained to go after tumors. CanVaxin, for example, a vaccine for the deadly skin cancer melanoma, is made from cancer-cell lines taken from three different patients; among them, they express more than 20 disabled tumor antigens that the immune system can learn to recognize...

Author: /time Magazine | Title: Vaccines Stage A Comeback | 1/21/2002 | See Source »

...average twice as long as controls. To make the vaccine even more potent, company scientists are testing a version of CanVaxin enhanced with cytokines to help boost the response of patients with immune systems damaged by chemotherapy. In Canada a vaccine called Melacine, made by Corixa, is also fighting melanoma, shrinking tumors as effectively as chemotherapy but with fewer side effects. It is currently in trials...

Author: /time Magazine | Title: Vaccines Stage A Comeback | 1/21/2002 | See Source »

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