Word: merck
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Cortisone is even scarcer than ACTH. Merck & Co., who make it, in 37 tedious steps, from the bile of butchered cattle, expect to produce little more than 1½ ounces a week for the rest of the year. Last week it was announced that henceforth cortisone will be doled out to suitable hospitals and research institutions through a committee of the National Academy of Sciences. And Merck has stopped giving it away: the price now is $60 for a 300-milligram vial ($5,670 an ounce...
Back from Germany in 1942 with doctorates in natural science and chemistry, Serrano taught at Guatemala City's San Carlos University and spent his spare time studying ixbut. Last week he had finished a 14-month series of experiments (in which Guatemala physicians cooperated) under contract for Merck & Co., and was busy writing his report...
...convinced," concludes Serrano, "that ixbut increases milk flow. By analysis, I know that this increment is actually milk and not water, as I originally suspected. We must still isolate the agent that causes the increase [a project which Merck & Co. will work on] and learn how it works." Serrano could rule out the milk-producing hormone prolactin: it did not enable his wife to nurse her four babies. But ixbut...
...early as 1941, Drs. Hench and Kendall speculated that an unknown "anti-rheumatic substance X" might be a hormone from the adrenal glands. In 1946, with the help of Merck & Co. chemists, they developed a compound from the adrenal glands of cattle. It was called Compound E (full name: 17-hydroxy-11-de-hydrocorticosterone). Compound E belongs to the steroid group of body chemicals. So do the sex hormones (a link with relief during pregnancy) and some bile products of the liver (a link with jaundice). Compound E was obtained later from an element of bile. Seven months ago Mayo...
Three drug-manufacturing firms (Squibb, Merck, Parke-Davis), experimenting with variations on streptomycin, found a complex chemical answer: dihydrostreptomycin (two atoms of hydrogen added to the original antibiotic). Two teams of doctors immediately started testing it. Last week the first public announcement of results was made in St. Paul, Minn. The news was hopeful...