Word: methyl
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Dates: during 1960-1969
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Last week at the National Institutes of Health in Bethesda, Md., cancer researchers intently observed 60 toadfish injected with an experimental anticancer drug, methyl GAG (for glyoxal-bis-gua-nylhydrazone). The researchers were trying to find out why the drug produces an undesirable side effect-lowered blood sugar. The toadfish is an ideal subject for such an experiment because it has simple kidney and insulin-producing mechanisms that permit researchers to observe sugar changes. To obtain blood samples, the researchers prick each toadfish's tail. To collect urine, they attach balloons to the excretory ducts of the toadfish...
Last week, in celebration of his great fortune, Akumu threw a little blast for 40 friends. He broke out the best in the house-a brand-new keg of uncut methyl alcohol, a volatile liquid most often used for boosting aircraft takeoffs. When the party was over, ten of the revelers were permanently blinded. Eight others, including Akumu Onyiego, were dead...
Among Nairobi's Africans, who judge an alcoholic beverage not by its taste but its kick, the most popular brew for the past 13 years has been a potion known as KMQ (Kill Me Quick), a throat-burning mixture of surgical spirits and methyl alcohol. Invented by a burly Luo tribesman named Akumu Onyiego, KMQ was precisely named: less than two pints of the stuff is a lethal dose...
...first sentence of Woodward's seven-page description of the synthesis, as reported to the Journal of the American Chemical Society, reads: "2 -(β, β-Dicyanovinyl)-3, 5-dimethyl-4-ethylpyrrole was converted by sulfuryl chloride in acetic acid at 55° to 2-(β, β-dicyanovinyl)-3-methyl-4-ethyl-5-chloromethylpyrrole [m.p. 189-192°], and thence, by condensation with 3-carbethoxy-4-methylpyrrole in hot aqueous etha-nolic hydrochloric acid to 3', 4-dimethyl-3-ethyl-4'-carbethoxy-5-(β, β-dicyanovinyl) dipyrrylmethane [m.p. 195-197°], which, with β-carbomethoxypropionyl chloride in dichloromethane...
...fact, they used four emboli, the surgeons reported in the A.M.A. Journal: tiny spheres of plastic (methyl methacrylate), with metal fragments inside to show up on X rays, and ranging from 2.5 mm. to 4.2 mm. in diameter. They opened the left side of the anesthetized patient's neck to expose the main branching of the carotid artery, principal supplier of blood to the brain. At 15-minute intervals they inserted successively larger plastic emboli. All came to rest at the base of the malformation, reducing its blood supply. The last and biggest pellet lodged for a while...