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Franklin is now studying the effect of baclofen on nicotine cravings. In one nine-week controlled trial involving 60 smokers, she found that those who worked up to a daily 80 mg dose of baclofen were able to reduce their smoking from 20.5 cigarettes a day to eight, a significant improvement over the placebo group, which was able to cut down to 12. And there was a distinct point at which the effect appeared to turn on - just like the switch discussed by alcoholics...
...panel, made up of scientists, doctors and consumer representatives, voted to make four major changes in the way acetaminophen is dispensed and packaged. First, it voted 21 to 6 in favor of lowering the maximum daily dose of nonprescription acetaminophen for adults, which is currently set at 4,000 mg; the panel did not specify a new maximum dosage. Second, the committee voted 24 to 13 to reduce the maximum single adult daily dose to 650 mg from the current maximum of 1,000 mg, or the equivalent of two tablets of Extra Strength Tylenol. Third, the members recommended...
...committee said that if combination prescription products were not stripped of their acetaminophen component, they should at least contain less of it - no more than 325 mg. (In some combination painkillers, the dose of acetaminophen can be as high as 750 mg...
...committee convened specifically to address liver toxicities due to acetaminophen overdose. The group of doctors and patient representatives concluded that the daily maximum dose of acetaminophen should be reduced from the current allowable 4 g and that the maximum single over-the-counter level be set at 650 mg, down from the current 1,000 mg...
...researchers thus recruited a small sample group of 10 men, ages 23 to 46; some of them got a placebo, while others took either 200 mg or 400 mg (typical therapeutic doses) of modafinil. All of the men's brains were then scanned using positron-emission tomography (PET scans). Volkow and Fowler were looking for dopamine activity - not just for overall dopamine levels, but also for the behavior of dopamine transporters...