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...team of Harvard researchers have identified a potential method for treating Huntington’s disease that might shed light on treatments for similar neurodegenerative diseases. The team—led by scientists at the Harvard-affiliated MassGeneral Institute For Neurodegenerative Disease (MGH-MIND)—identified a novel mechanism of clearing disease-causing mutant huntingtin protein from brain cells by modifying the protein structure for autophagic degradation, a natural degradation process in cells. The introduction of a specific molecular fragment known as an acetyl group into the mutant proteins—a process also known as acetylation?...
...Bacskai and researchers at MIND are in the process of using these imaging techniques to study other neurodegenerative diseases. “The point of MIND is to have all the researchers in an open lab environment,” said Anne B. Young, the chief of neurology at MGH and the director of MGH-MIND. “When somebody like Brian finds a new way of looking at something like Alzheimer’s disease we can then go quickly to looking at the same issues in other diseases.” —Staff writer Alissa...
Three years ago, MIT obtained the first of two MRI machines in a similar transition away from MGH Charlestown. According to Steven Shannon, an operations manager and MR research technologist at MIT, their primary machine now operates twelve hours a day, every day, to support MIT-affiliated research...
...years to become the director of the Yale Cancer Center and physician-in-chief of the Smilow Cancer Hospital at Yale New Haven Hospital, Yale announced Wednesday. “They gave me the opportunity to take some of the lessons I learned in the phenomenal success of MGH and apply it in a setting like Yale,” Lynch said. “It was an opportunity that was irresistible.” He said that Yale is making a major investment in cancer research, both in clinical care and translational research, and that he has a once...
...surgery centers. In recent years, several of Boston’s city hospitals—including the HMS affiliated and top-ranked Massachusetts General Hospital, Beth Israel Deaconess Medical Center, and Children’s Hospital Boston—have planned and embarked on multi-million dollar expansion projects. MGH, the largest hospital in New England and the third oldest general hospital in the U.S., broke ground last September on a $144 million outpatient care facility in Danvers. While the new regulations should not affect the Children’s Hospital’s proposed expansion plans in the North...