Word: mice
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Dates: during 1990-1999
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...seemed too good to be true, and of course it was. There are no miracle cancer drugs, at least not yet. At this stage all EntreMed can offer is some very interesting molecules, called angiostatin and endostatin, and the only cancers they have cured so far have been in mice. By the middle of last week, even the most breathless TV talk-show hosts had learned what every scientist already knew: that curing a disease in lab animals is not the same as doing it in humans. "The history of cancer research has been a history of curing cancer...
...piece in the Times and the prominent placement her editors gave it. "Within a year," she began, "if all goes well, the first cancer patient will be injected with two new drugs that can eradicate any type of cancer, with no obvious side effects and no drug resistance--in mice." It was a sentence that couldn't help grabbing readers' attention--despite those critical two words, "in mice"--and holding it throughout the rest of the story...
...matter what its configuration, angiostatin could not make a mouse tumor disappear. Not, that is, until Folkman and O'Reilly added to the mix a second molecular fragment, which they called endostatin, from yet another naturally occurring protein. Together, the two compounds destroyed a range of tumors in mice. The results were startling enough that they merited testing in people--which is exactly what Pluda, at the National Cancer Institute, intends to do. How fast those studies can begin depends on how much angiostatin and endostatin EntreMed and its business partner, Bristol-Myers Squibb, can produce and whether they...
Last week's miracle-in-mice may have launched a thousand premature hopes, but there's no doubt in the minds of cancer researchers today that a new era is dawning in the treatment of the U.S.'s No. 2 killer. Three decades ago, the Federal Government's "War on Cancer" underwrote basic discoveries about the ways broken-down genes lead to malignancies. Now that work is beginning to pay off. "The black box that was the cancer cell has been opened," says Dr. Bert Vogelstein, a world-renowned investigator of cancer genes at the Johns Hopkins University in Baltimore...
...operations at the Air Force Academy and cleanup at the Rocky Flats former nuclear-weapons site. With the certainty of greater disruption if the animal wins federal protection, Colorado officials have organized a 200-member coalition to draft the state's own protection plan, which may include finding the mice and relocating some of them into sanctuaries. "It's in the interest of both mouse and man to avoid drastic measures," says Congressman David Skaggs of Boulder, a Democrat who secured a $400,000 appropriation to fund the project. "Nobody wants an endangered-species train wreck in the areas where...