Word: mice
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Dates: during 1990-1999
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Tsai and her team have recently isolated a gene in mice, called p35, which appears to play an integral part in the formation of the cortex...
...elucidate the gene's effects, Tsai used a recently-developed technique which allows researchers to selectively create "knockout mice"--mutant mice who are lacking in a specific gene. The researchers can then study the effect the loss has on the mutants by recovering the excited gene for study...
Tsai says the mice lacking the gene were "not as active," were uncoordinated and walked unsteadily. Although they were still fertile, the mothers "displayed nurturing defects...
...most importantly, Tais says, the mice "were especially sensitive to suffering fatal seizures...
...mutant mice, the corpus callosum--the bundle of fibers which connects the two hemispheres of the brain--was almost non-existent. Additionally, the general pattern of connections in the rest of the cortex seemed to be highly altered...