Word: mice
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Dates: during 1990-1999
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...many people struggling mightily to keep their weight in check wouldn't trade places with the mice in Dr. Jeffrey Friedman's laboratory? Two weeks earlier, these roly-poly fur balls weighed three times as much as a mouse should, and they still couldn't stop snacking. After daily injections of a new hormone, however, the tubby rodents suddenly started consuming less food and burning more fat. They shed those excess ounces and trimmed 30% off their bloated size. Even better, their cholesterol readings fell, as did the high glucose levels that made them mildly diabetic. Virtually overnight, it seemed...
...answer may be in the genes. That's the tantalizing conclusion of a team of researchers from the University of Geneva in Switzerland. They have discovered that genes associated with the formation of fins in fish are the same ones that orchestrate the development of paws in mice. "Think of a mouse as a fish with limbs, or a fish as a mouse with fins," says University of Geneva developmental biologist Denis Duboule. "What a mouse does is take a fin and put something extra...
...animals), feet do not grow straight out of the leg, proceeding from the ankle out, but develop in a fanlike progression that runs from the smallest digit to the largest. In Geneva, Duboule and his colleagues tracked the activity of four Hox genes in the budding feet of embryonic mice and found precisely this pattern. By contrast, studies showed that in the zebrafish, the Hox genes switch off earlier, perhaps to ensure that a flexible fin ray (useful for swimming) will form in the place of feet. Duboule speculates that if these genes could be tricked into staying on just...
...week study, mice that had been injected with human melanoma cells were treated with clotrimazole. Those that received the drug had significantly reduced cancerous growth...
...studios want his clients and will pay hugely for them. As MCA czar, he would have been a buyer in that market. The fellow who helped jack up the price of the product would now be asked to run a lean, mean company. It's like putting the mice in charge of the pantry...