Word: mice
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Dates: during 2000-2009
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...Left on her own, Coraline wanders through the huge old house, now divided into several large apartments, to meet the other residents: Mr. Bobinsky (Ian McShane), an eight-foot-tall blue Russian who runs a circus of more-or-less trained mice; and Miss Spink (Jennifer Saunders) and Miss Forcible (Dawn French), a pair of venerable theatrical troupers endlessly recounting their glory days in the music hall. Coraline also meets a boy her age, Whybe Lovet (Robert Bailey Jr.), the grandson of the grande dame who owns the place, and a talking cat (Keith David) with dark secrets he eventually...
Harvard researchers have successfully tested a new cancer vaccine in mice that could make previously expensive treatments accessible outside state-of-the-art medical centers. The therapy—which destroyed tumors in 90 percent of mice tested—uses small implants to avoid costly cell reprogramming outside the body. The latter technique requires practitioners to have extensive training and specialized facilities that are only available at elite hospitals. The findings, published in the journal Nature Materials last month, seek to combat those tumors that fool the immune system’s normal process of identifying dangerous substances. Normally...
...become obvious until 1963, when Canadian researchers Ernest McCulloch and James Till first proved the existence of stem cells, in the blood. These cells possess the ability to divide and create progeny - some of which will eventually expire, others that are self-renewing. The pair irradiated mice, destroying their immune cells. They then injected versatile bone-marrow cells into the animals' spleens and were surprised to see a ball of cells grow from each injection site. Each mass turned out to have emerged from a single stem cell, which in turn generated new blood cells...
...Melton's team has already replaced two of the genes with chemicals, and he anticipates that the remaining ones will be swapped out in a few years. There are also hints that the iPS cells' short-circuited development makes them different in some ways from their embryonic counterparts. In mice, embryonic stem cells can generate a new mouse clone; iPS cells from the animals have so far stopped short of the same feat, aborting in midgestation, suggesting that some development cues may be missing. "It certainly makes me cautious," says Eggan...
...September Konrad Hochedlinger at Harvard creates iPS cells in mice using the common-cold virus rather than retrovirus vectors - an important step in making the technology safer for human...