Word: miceli
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Dates: during 1990-1999
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...Americans have been infected with the disease. Now endemic throughout the Northeast as well as parts of the Midwest and the West Coast, Lyme disease is caused by a corkscrew-shaped bacterium called Borrelia burgdorferi. It is spread by the bite of ticks that usually live on mice and deer but also attach themselves to other warm-blooded creatures, including people. Typically, within a month of a bite, a large, bull's-eye rash shows up at the site, accompanied by chills, fever, headache and painful joints. Untreated, the infection may eventually lead to severe arthritis, facial palsy and irregular...
...puzzle provided for the pleasure of those temperamentally inclined to endless research. The entire question of how best to spend our resources needs to be debated because we are proceeding on blind faith that is unsupported by positive results after decades of research. Scientists continue to work with mice, knowing that what is learned seldom applies to humans. The cancer-research juggernaut has been rolling for way too long now, costing too many dollars and too many lives. LAWRENCE BLAKELY BARNES Bangkok...
...DEER MICE: In the U.S. Southwest, rains have made life easier for this carrier of the deadly hantavirus...
Trouble is, Black 6 and kin often do their jobs too well. "Mice distort or exaggerate what you see in humans," says tumor biologist Robert Kerbel of Toronto's Sunnybrook Health Science Centre. Mouse tumors, which are usually planted just under the skin, grow much more rapidly than deep-seated human tumors. Also, as Nobel laureate J. Michael Bishop observes, too much breeding isn't always a good thing. In his labs at the University of California, San Francisco, he is genetically altering mice to provide better models for studying leukemia and neuroblastoma, the most common tumor in children under...
Similar or not, no one, except perhaps a few animal-rights activists, is about to chase mice out of the lab. Mice save lives. Because their tumors develop almost overnight, says Merck's Oliff, "we can do tests 10 or 100 times more quickly than in humans." Their usefulness varies with diseases, though. He notes that rodents are better predictors of human reaction to cardiovascular or anti-inflammatory agents than to cancer or diseases of the central nervous system. But that's a trade-off researchers are more than willing to accept in their search for a cancer cure...