Word: miceli
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Dates: during 2000-2009
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Both Celera and the Human Genome Project will go after new genomes--among them that of the mouse. (Tellingly, the government researchers are expected to adopt Venter's technique for this task.) Reason: not only are mice useful to test potential treatments, but also--because they share many of our genes--they offer an alternative route to understanding how genes work and how they can cause disease...
That kind of redesign isn't possible today, but it may not be far off. Scientists at the University of Pennsylvania Medical School have already developed a way to equip a benign virus with genetic material that codes for muscle growth, and they have injected the virus into mice. The animals quickly bulk up by as much as 20%, becoming not just bigger but stronger. The researchers have developed other techniques to block cellular signals that would otherwise cause muscles to atrophy, allowing the new mass to be retained even without exercise...
...Browder, who was working full-time in Folkman's laboratory, began experimenting with non-standard treatment regimens that utilized a standard chemotherapy drug, Cytoxan. He eventually developed a treatment schedule that appeared to inhibit the regeneration of endothelial cells--the cells that line blood vessels--in test mice...
...addition, giving lower doses of the standard drug proved "more effective and less toxic" in mice, the statement said...
...researchers have said that despite the promising findings, they are cautiously optimistic, in part because the study only used mice as its subjects...