Word: miceli
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Dates: during 2000-2009
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...group of Harvard researchers at Boston Children's Hospital say they have cured cancer in mice by applying new methodology to a standard cancer treatment--chemotherapy...
...data give statistical support to a long-suspected theory that cutting off a tumor's blood supply may shrink it. The article reports that when lower doses of traditional chemotherapy drugs were given more frequently to inhibit blood cell growth--known as angiogenesis--in test mice, 100 percent of drug-sensitive tumors were cured...
...mice whose cancer had become resistant to traditional chemotherapy schedules, the new treatment regimen was three times as effective as the standard regimen in suppressing tumor growth. The standard regimen entails higher doses of chemotherapy drugs, administered less frequently...
...study also examined the effect of combining the traditional chemotherapy drugs with an experimental drug that attacks the tumor's blood supply. According to the report, 84 percent of mice with tumors that were unresponsive to traditional chemotherapy drugs were cured when the standard chemotherapy drug was combined with a low dose of an angiogenesis inhibitor...
Because the tumors in question had been unresponsive to the traditional chemotherapy treatment, Folkman said, the study lends support to the theory that it is possible to halt and reverse cancer growth in mice with a "flanking maneuver"--targeting blood cells surrounding the tumor but not the tumor itself...