Word: miceli
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Dates: during 2000-2009
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Wouldn't it be more effective if banked blood could simply be improved? Stamler's study suggests it can: by replacing nitric oxide in stored blood, Stamler showed that the risk of heart attack and death from transfusion dropped dramatically, at least in mice. And there's reason to believe such replenishment could work in human patients as well; already, premature babies born with lung and respiratory problems are placed in NO-rich environments to ensure that their still developing tissues get the oxygen they need to grow properly. For now, the American Red Cross, which oversees 14 million units...
...could already see by looking at the intestine under the microscope that bad things were happening by three, three-and-a-half weeks of age,” said Glimcher, who authored the study. “A hundred percent of the mice got the disease—a very aggressive disease. We pretty much had to euthanize the mice by the time they were 12 weeks...
...mice had been genetically altered to lack a protein called ‘T-bet,’ which the researchers now believe acts as a ‘peacekeeper,’ preventing harmful bacteria from breaching the single layer of cells which protects the rest of the body from the microbe-infested...
...study found that the mutant mice could also transmit the disease to other mice through feces, suggesting the genetic defect encourages the growth of aggressively infectious bacteria...
...also noted the possibility of using the mutant mice to study colon cancer, which long-term colitis patients have a heightened risk of developing...