Word: miceli
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Dates: during 2000-2009
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When a family of genetically modified mice started dying in a Harvard School of Public Health lab, researchers were puzzled...
...come you have so many cages of these mice breeding but don’t seem to have enough mice to do experiments?” Laurie Glimcher, a professor of immunology at the School of Public Health, recalled asking...
...some experts, such as Boston College's Thomas Seyfried, say it's still a remarkable achievement. Seyfried has long called for clinical trials of low-carb, high-fat diets against cancer, and has been trying to push research in the field with animal studies: His results suggest that mice survive cancers, including brain cancer, much longer when put on high-fat diets, even longer when the diets are also calorie-restricted. "Clinical studies are highly warranted," he says, attributing the lack of human studies to the medical establishment, which he feels is single-minded in its approach to treatment...
...mystery may have been solved, by a team of neuroscientists at MIT's Picower Institute for Learning and Memory. Researcher Thomas McHugh and several colleagues have uncovered a specific memory circuit in the brains of mice that is probably the cause of this weird sensation, which turns out to be a sort of memory-based analogue of an optical illusion. Although neuroscientists have realized for some time that memory is made up of many different components--long and short term, episodic (that is to say, memories of events) and fact based, and that it takes place in different parts...
...they used genetic engineering to create a mouse without this crucial gene and devised an experiment to test the hypothesis. The mice were guided into a box where they would get a mild foot shock; they would react by freezing. Then they were guided into a very similar box with no shock. The altered mice would freeze in the safe box as well, and it took them a long time to figure out the difference. Normal mice figured it out pretty quickly...