Word: miceli
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Dates: during 2000-2009
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Grant theorizes that trichotillomania may be a kind of grooming irregularity that falls into the obsessive-compulsive family of disorders. "Some parrots pull out all their feathers," he says. "Some mice pull out all their...
Because of their late start (researchers had intended to study mice from early ages but were stymied by technical difficulties), scientists weren't sure they could expect clear results. However, even administered late in life, rapamycin delayed the deaths of the longest-lived male mice by 101 days and by 151 days in the longest-lived females - the equivalent of about 13 years on average in humans - compared with mice with no treatment. In terms of life expectancy when treatment began (or average remaining lifespan when the mice were 600 days old), that translates to an increase...
...this cellular efficiency, perhaps, that delays aging and helps preserve animals' good health. The findings suggest that rapamycin does not affect or prevent any one disease specifically - the mice in the study died of various causes, with no real difference between mice that received rapamycin and those that didn't - but rather that it slows aging overall. (Read a TIME cover story on the science of aging...
...rapamycin] for age-related diseases like Alzheimer's disease, Parkinson's disease or kidney disease." The drug has also recently entered clinical trials as a human cancer treatment, while another study published last year showed that it may reverse mental retardation caused by the genetic disease tuberous sclerosis in mice. (See TIME's photo-essay "Access to Life...
...agents for extending life, other drugs may be further along in the pipeline - resveratrol, for one, which has also prolonged life in lab mice. But the new finding by Strong and his colleagues "more clearly identifies the [target of rapamycin] pathway as important across species." It may guide researchers to target different proteins in the same pathway. "If those proteins react the same way to extend lifespan, then we might be able to get rid of unwanted side effects," says Strong...