Word: miceli
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Dates: during 2000-2009
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...view radically changed in the late 1950s when Swedish pharmacologist Arvid Carlsson brought dopamine out of the shadows. First Carlsson established that the areas of the brain known as the basal ganglia contained very high levels of dopamine. Then he administered a drug that lowered those concentrations in laboratory mice. Soon the mice began to stagger and reel, losing control of their voluntary movements...
Carlsson's mice, in other words, resembled human patients with Parkinson's disease--and L-dopa, the dopamine-boosting compound he used to restore normality to the mice, soon emerged as the frontline treatment for Parkinson...
...careful about generalizing extensively from observations in the roundworm," said Dr. Richard Weindruch, who studies aging in mice at the University of Wisconsin. "It's not clear to what extent these findings represent the situation in mammals...
...role insulin plays in aging in mice is not yet known, but when mice are placed on a restricted diet, which lowers their insulin levels, they live longer...
Harvard has licensed worldwide rights to the mice, which were developed by Andrus Professor of Genetics Phillip Leder '56, to chemical giant DuPont...