Word: miceli
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Dates: during 2000-2009
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...Stem-Cell-Created Mice The birth of yet another laboratory mouse is hardly worth noting - unless the furry creature is the first to be developed from stem cells that do not involve embryonic cells. That deserves to be called a breakthrough. The new pups, whose creation in two separate labs in China was announced in July, were the first to be bred from induced pluripotent stem (iPS) cells. These are adult cells (usually skin cells) that scientists reprogram back to their embryonic state by introducing four genes. The reprogrammed stem cells are then programmed again to develop into mice...
...team of Harvard bioengineers and biologists say that they have developed a cancer vaccine that eradicates melanoma tumors in mice and slows their reoccurrence...
...When we inject cancerous cells, memory of the immune system is sustained,” Ali said. “Tumors grow at slower rate and some mice don’t develop tumors...
Though this cancer vaccine is limited to use in mice, researchers at InCytu, Inc.—the company that owns the license for the rights of the vaccine—are looking to extend research to test the vaccine on other types of cancer and expand to human clinical trials...
...single gene injected into the monkeys was coded for the naturally occurring protein follistatin, which blocks the function of another protein called myostatin that hinders muscle growth. Past research in mice that were genetically engineered to have an extra copy of the follistatin-producing gene has shown that blocking myostatin, by increasing follistatin, causes muscles to bulk up fast. What Kaspar and his team found was that the same effect could be achieved simply by injecting genes - ferried aboard a small, non-disease-causing virus known as AAV, or adeno-associated virus - into the muscle. They further discovered that once...