Word: miceli
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...natural compound used as an immunosuppressant in organ-transplant patients has been found to extend life in mice, according to a study published on July 8 in the journal Nature. Aging mice that were given the substance, rapamycin, lived significantly longer than mice that didn't get the drug: females that received rapamycin were 13% older at death and males 9% older...
...research, conducted as part of the National Institute of Aging Interventions Testing Program, took place at three separate test sites and involved nearly 2,000 genetically similar mice. Trials began when mice were about 600 days old - well into middle age, at a stage roughly equivalent to 60-year-old humans. (See the top 10 medical breakthroughs...
Because of their late start (researchers had intended to study mice from early ages but were stymied by technical difficulties), scientists weren't sure they could expect clear results. However, even administered late in life, rapamycin delayed the deaths of the longest-lived male mice by 101 days and by 151 days in the longest-lived females - the equivalent of about 13 years on average in humans - compared with mice with no treatment. In terms of life expectancy when treatment began (or average remaining lifespan when the mice were 600 days old), that translates to an increase...
...this cellular efficiency, perhaps, that delays aging and helps preserve animals' good health. The findings suggest that rapamycin does not affect or prevent any one disease specifically - the mice in the study died of various causes, with no real difference between mice that received rapamycin and those that didn't - but rather that it slows aging overall. (Read a TIME cover story on the science of aging...
...Everyone acknowledges that 1939 was a vintage Hollywood year for films. Gone With the Wind won eight awards, including Best Picture, defeating three other adaptations of famous novels - Wuthering Heights, Of Mice and Men and Goodbye, Mr. Chips - and Frank Capra's all-time rabble-rousing political drama Mr. Smith Goes to Washington. If there'd been just five slots, the roll call might have ended there. But since 10 was the magic number, there was room for two transcendent weepies, Dark Victory (Bette Davis loses her sight) and Love Affair (Irene Dunne loses her legs), plus a musical...