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...headquarters now holds blood samples from about 100,000 individuals, roughly half of Iceland's adult population. Using those samples, scientists at the company were able to zero in on their new anti-heart-attack compound. It's based on a gene known as LTA4H, first seen in mice, which governs the production of an enzyme called leukotriene A4 hydrolase. The enzyme plays a role in inflammation, a key factor in heart disease, and also encourages the buildup of cholesterol on blood-vessel walls...

Author: /time Magazine | Title: The Iceland Experiment | 2/12/2006 | See Source »

Imagine you could unlock the secrets of Alzheimer's or Parkinson?s disease just by dissecting the brains of a few mice. Now imagine that the reason those mice were so revealing was because those brains were at least partly human...

Author: /time Magazine | Title: Viewpoint: The President and the Minotaur | 2/3/2006 | See Source »

...what if some of those specially bred mice started showing a particular fondness for Mozart? Or poker? Would it still be OK to cut them open and look inside...

Author: /time Magazine | Title: Viewpoint: The President and the Minotaur | 2/3/2006 | See Source »

...questions like these, which have hovered around the Stanford researchers who have been working on growing human brain cells in mice, that gave rise to one of the more surprising moments in President Bush?s otherwise unsurprising speech Tuesday night...

Author: /time Magazine | Title: Viewpoint: The President and the Minotaur | 2/3/2006 | See Source »

...American researchers have created pigs with human blood, sheep with partially human brains, livers, hearts, and of course, the brainy mice. Such experiments are grounded in all kinds of hopes: hope for a way to relieve the heartbreaking shortage of organs for transplant, for example, or for testing new drugs and treatments on a more nearly human animal to better judge what works. Other researchers are introducing animal DNA into human embryos as a kind of marker, to help them understand how disease develops. Some research involves the intentional creation and destruction of human embryos, however, which is controversial...

Author: /time Magazine | Title: Viewpoint: The President and the Minotaur | 2/3/2006 | See Source »

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