Word: miceli
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...mystery seemed solved when I placed the disc in my “now playing” stack, right above Mice Parade’s “Bem-Vinda Vontande.” I had come to possess, in the span of only a few days, no less than two albums by bands that had forgone the traditional route of titling their albums in English...
Some appear perfectly pedestrian, with the warm white fur and beady pink eyes of pet-store mice. Others are clearly extraordinary, waddling about on paws shaped like miniature dolphin flippers or swollen to the size of their larger relative, the rat. They are called transgenic mice, and in a nobly selfless fashion, they are revolutionizing modern biology. Hidden somewhere along the twisting chain of DNA found in every cell of their bodies are alien genes, injected by biologists. The study of these mutants and the effects of the interloping genes may help provide answers to such fundamental questions as what...
...Palmiter of the University of Washington in Seattle and their colleagues concocted a sort of two-part genetic mongrel. They fused a gene that produces rat growth hormone to a powerful regulatory switch cleaved from a mouse gene. That construct in hand, the scientists mated normal male and female mice, and then removed the fertilized eggs from the female before the egg and sperm nuclei had combined. Viewing the cell beneath a microscope and wielding a glass micropipette less than the width of a human hair, the researchers injected their fusion construct into the larger male nucleus and then implanted...
Their strategy worked beautifully. The growth-hormone gene was incorporated into the DNA of about a third of the mouse pups and, most important, was activated in a variety of tissues. These offspring, spurred on by the extra portion of growth hormone, ballooned to twice the size of normal mice. What is more, because the new gene was present in all their cells, including their sex cells, it was passed along to the next generation. Says Brinster: "We're now doing work on the seventh generation of Supermouse...
...understand better the genetic basis of cancer, Philip Leder, a molecular geneticist at the Harvard Medical School and his colleague Timothy Stewart, have bred a line of transgenic mice that may someday serve as a model for human breast malignancy. He designed a DNA hybrid consisting of a gene called c-myc, which has been implicated in animal and human cancer, linked to a regulatory segment of another gene that is expressed in developing and lactating breast tissue. Soon after female mice with the injected gene give birth and begin nursing, they grow sizable tumors in their breasts. Perhaps more...