Word: miceli
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...physical characteristics of an organism was proposed in the 1970s, yet it wasn't until 2003 that anyone experimented with DNA methylation quite as dramatically as Duke University oncologist Randy Jirtle and one of his postdoctoral students, Robert Waterland, did. That year, they conducted an elegant experiment on mice with a uniquely regulated agouti gene - a gene that gives mice yellow coats and a propensity for obesity and diabetes when expressed continuously. Jirtle's team fed one group of pregnant agouti mice a diet rich in B vitamins (folic acid and vitamin B12). Another group of genetically identical pregnant agouti...
...epigenetic inheritance doesn't last forever, it can be hugely powerful. In February 2009, the Journal of Neuroscience published a paper showing that even memory - a wildly complex biological and psychological process - can be improved from one generation to the next via epigenetics. The paper described an experiment with mice led by Larry Feig, a Tufts University biochemist. Feig's team exposed mice with genetic memory problems to an environment rich with toys, exercise and extra attention. These mice showed significant improvement in long-term potentiation (LTP), a form of neural transmission that is key to memory formation. Surprisingly, their...
...Stem-Cell-Created Mice The birth of yet another laboratory mouse is hardly worth noting - unless the furry creature is the first to be developed from stem cells that do not involve embryonic cells. That deserves to be called a breakthrough. The new pups, whose creation in two separate labs in China was announced in July, were the first to be bred from induced pluripotent stem (iPS) cells. These are adult cells (usually skin cells) that scientists reprogram back to their embryonic state by introducing four genes. The reprogrammed stem cells are then programmed again to develop into mice...
...When we inject cancerous cells, memory of the immune system is sustained,” Ali said. “Tumors grow at slower rate and some mice don’t develop tumors...
Though this cancer vaccine is limited to use in mice, researchers at InCytu, Inc.—the company that owns the license for the rights of the vaccine—are looking to extend research to test the vaccine on other types of cancer and expand to human clinical trials...