Word: miceli
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...trials with LDP341, a proteasome-inhibiting substance that is showing promise against multiple myeloma and chronic lymphocytic leukemia. Phase I studies on the top five solid tumors (breast, pancreatic, prostate, lung and colon) are under way, and at this point the inhibitor seems to be working?at least in mice...
...Folkman's insight was to look for substances that prevent tumors from building those pipelines. This approach worked beautifully in mice. Now more than 50 angiogenesis inhibitors are being studied in humans with a wide range of cancers; a dozen are in the final stages of testing. Thus far, only a tiny number of human patients treated with these compounds have seen their tumors shrink or disappear. Clinicians are nonetheless encouraged; while angiogenesis inhibitors don't make cancer go away, they do appear to slow tumor growth. And that means they may work best in conjunction with some...
...called epidermal growth factor (EGF). It's a close cousin to HER2, and Mendelsohn and his team know that it is present in a huge variety of tumors; two-thirds of all cancer types, in fact, are blanketed with EGF receptors. In 1984 Mendelsohn and his team showed in mice that blocking the EGF receptor with a growth-factor decoy prevented a cell from growing and dividing...
...trials with LDP341, a proteasome-inhibiting substance that is showing promise against multiple myeloma and chronic lymphocytic leukemia. Phase I studies on the top five solid tumors (breast, pancreatic, prostate, lung and colon) are under way, and at this point the inhibitor seems to be working--at least in mice...
Folkman's insight was to look for substances that prevent tumors from building those pipelines. This approach worked beautifully in mice. Now more than 50 angiogenesis inhibitors are being studied in humans with a wide range of cancers; a dozen are in the final stages of testing. Thus far, only a tiny number of human patients treated with these compounds have seen their tumors shrink or disappear. Clinicians are nonetheless encouraged; while angiogenesis inhibitors don't make cancer go away, they do appear to slow tumor growth. And that means they may work best in conjunction with some...