Word: miceli
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...venom contains a protein, contortrostatin, that retards the growth and metastasis of tumors. Markland's team has found that injections of contortrostatin not only prevent the spread of ovarian and breast tumors in mice but also shrink them as much as 75%. The group hopes to start clinical trials of contortrostatin in about two years...
...suggestion that drug designers might be on the right track comes from studies of mice that have been genetically engineered to develop Alzheimer's-like plaques. These mice exhibit at least some symptoms of memory loss, performing less well on tests that measure how long it takes them to get back to the one dry platform researchers have positioned out of sight in a watery maze. There are now strong hints that retarding the development of plaques helps preserve intellectual performance, at least in rodents. And that raises an intriguing question: Might getting rid of plaques once they have developed...
...says Bristol-Myers' Molinoff. "But there's now intriguing evidence that suggests you can get plaque regression." Some of the most striking evidence comes from studies of a vaccine against beta amyloid that Schenk and his co-workers at Elan have developed. In 1999 they administered their vaccine to mice whose brains were filled with plaques. A short time later, the plaques shrank. Currently the Elan vaccine, like the Bristol-Myers' secretase inhibitor, is in early-phase clinical trials, in which the primary objective is to test for safety as opposed to effectiveness...
...discovery of leptin in 1994 that got the genetic study of obesity rolling, and it was Friedman's research team that was responsible. Studying the genome of a rare strain of hugely obese mice, the investigators found that all of them shared a defect in a gene that coded for a previously unknown hormone released by body fat. When a normal animal gains too much weight, the hormone signals the brain to turn down the appetite rheostat. When fat stores drop, the hormone is shut off, causing appetite to rebound. In the gene-damaged mice, there was no leptin...
...explain the literally unprecedented Harry Potter phenomenon, starting with Rowling, now 35, whose life has been changed utterly by the product of her imagination. Seven years ago, she was the single mother of a small daughter, living in a two-room flat in Edinburgh, listening to mice skittering behind the walls. Now she is internationally famous and earning, according to various estimates, somewhere in the range of $30 million to $40 million a year. Once, during a bad patch, she dreaded the hostile looks she would attract while lining up at the local post office to claim her weekly income...