Word: midazolam
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...Vietnam War and now chairs the department of anesthesia at the University of California, San Francisco, School of Medicine; it's hard to imagine someone with more experience or better credentials. Even so, he was taken by surprise when he gave a low dose of a moderate sedative called midazolam, designed to put the patient into a semiconscious state, somewhere between sleep and wakefulness--and the man stopped breathing. "There is no way of predicting that a patient would have responded that way," he says. "I've been doing this for years, so I was prepared." He managed to revive...
...CALMER A quick spritz with a nasal spray may help youngsters get through difficult medical procedures a lot more easily. That's the conclusion of a Swedish study that assessed the soothing effects of a spray containing the antianxiety drug midazolam on kids receiving intravenous cancer medication. All the children who got the spray reported they were better able to tolerate their cancer treatment. Researchers think the spritz may also help youngsters facing routine procedures like vaccinations...
...that is distinct from anesthesia--before surgery, in contrast to 75% of adults. The push to change the way youngsters are prepped got a big boost this spring when Dr. Zeev Kain of Yale reported that in the first week after an operation, children given the liquid form of midazolam (the most commonly used preoperative sedative) experience 25% to 50% fewer nightmares and other disturbances than those given a placebo...
...being tested is a benzodiazepine compound called Midazolam; it induces deep sleep for short periods (90 min. at most) and might be an alternative to general anesthesia in surgery. Another drug, called only No. 5057, could improve memory and other mental functions by allowing more oxygen to reach brain cells. Roche Researcher Willy Haefely says this could help retard senility "or sharpen the mind of an executive suffering from a hangover." He concedes that "unfortunately, we will never be able to produce geniuses with drugs." But if Roche can develop another winner like Valium, it might ease much...
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