Word: milano
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...heydays and its low days, and architecture follows that." For home furnishings, he shops at places like the EntrataLibera contemporary furniture store, which showcases young designers, as well as E De Padova, a store famous for its window displays. Inspirational books, like a recent George Nakashima edition, come from Milano Libri, a bookstore near Maier's office. "As a designer, you need to constantly step back and get perspective," he says. "So I never look at fashion." --By Kate Betts
...news reports dubbed it "Drano for the heart," and if the results are confirmed in larger trials, they may signal an exciting new approach in fighting cardiovascular disease, America's leading cause of death. "It" is a genetically rare type of HDL, or "good" cholesterol, dubbed ApoA-1 Milano. First identified 30 years ago in a small group of people living in northern Italy, this super HDL is even more protective against heart disease than regular HDL. In a study released this past fall, researchers injected a synthetic version of ApoA-1 Milano into 47 patients and found that unlike...
Further study revealed that their HDL was of a rare type, later named ApoA-1 Milano, that is evidently much more protective than ordinary HDL. In the 1990s Dr. P.K. Shah of Cedars-Sinai Medical Center in Los Angeles injected a synthetic version of this variant HDL into rabbits and mice. He showed that ApoA-1 Milano could not only reverse plaque buildup but also stabilize and reduce inflammation of what was left...
...ApoA-1 Milano eventually became the property of Esperion Therapeutics, in Ann Arbor, Mich., which persuaded Nissen to conduct the studies that led to last week's report. If the results hold up in larger trials, they could be revolutionary. Statin drugs, which lower the bad LDL cholesterol that causes plaque in the first place, reduce the risk of dying from heart disease only 30% or so. By targeting HDL as well, the risk might be halved. Says Nissen: "We're starting to talk about really limiting what this disease...
...equivalent of New Yorkers' electing Sylvester Stallone Governor after 9/11. Running a state the size of California is not a job one just walks into. Californians must realize what they need is not an actor but someone with the experience necessary to get the state back on track. BEN MILANO Lindenhurst...