Word: millenniums
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Here in Cambridge, a new industry is quietly taking shape that proposes to do that on a grand scale, as companies with names like Biogen, Genzyme, Genetics Institute and Millennium Pharmaceuticals--Zeus' home--prepare to change forever the way doctors fight disease. They're not alone: spurred by the prospect of scientific glory and enormous profit, big pharmaceutical firms and university and government labs have been joined by scores of new companies, not just in Cambridge but in Montgomery County, Md., Silicon Valley and other high-tech hot spots around the nation. It's a virtual gold rush to mine...
Sifting through the human genome for therapeutically useful gems, though, requires a well-designed search strategy combined with powerful technology. At Millennium, housed in a factory that once stamped out heart-shaped candy boxes for Valentine's Day, that strategy is embodied in Zeus, whose job is to find the handful of genes among the genome's tens of thousands that are key to individual diseases--and thus key to making effective medications...
...make this search as easy as possible, Millennium chief scientific officer Dr. Robert Tepper has chosen to focus on the low-hanging fruit--going first for the most obvious targets. In looking for anticancer drugs, for example, his researchers are concentrating on monoclonal antibodies, a type of biological "smart bomb" that targets cancer cells and leaves normal cells alone. Like all antibodies, these man-made cancer missiles seek out particular receptors--molecules on the cancer cell's surface that help the cell recognize and react to nearby enzymes and proteins. Almost a dozen such drugs are already on the market...
Just as the whole world was a bit hasty in ushering in a new millennium last year when the old one still wasn't finished, many saw fit to declare their year's "best in music" lists before the year was actually over. But the Sampler bided its time, waiting wisely till the last plink was plunked before tipping its hand...
...begin the term after Labor Day. But such mindless adherence to antiquated tradition reflects poorly on an institution dedicated to the cultivation of reason. The archaic idea that finals should occur after winter break has vexed undergraduates for too long, and now, in the first year of the new millennium, the University should take the bold step of revamping our schedule to join the rest of the modern world...