Word: milligrams
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Dates: during 1970-1979
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...industry must find Gofman's credentials no less shocking than his message. For his Ph.D. dissertation he discovered four chemical isotopes, including uranium 232 and 233, and patented the fissionability of the latter. Next he served as a Group Leader with the Manhattan Project team that isolated the first milligram of plutonium. Then he picked up an M.D. and was appointed Professor of Medical Physics at Berkeley. In the 1960s he was associate Director of the Lawrence Livermore Lab, one of two research centers where all U.S. nuclear weapons are developed...
Dart Guns. Six-tenths of a milligram of saxitoxin can kill an adult, often within an hour, by blocking the transmission of impulses in the nervous system-just as in Fleming's account. Saxitoxin is produced by a single-cell sea creature that flourishes during the warmest months. Oysters, clams and mussels that eat the organism are poisonous to humans, which is why in some areas such seafood is not harvested in summer. By contrast, fugu poison, which has almost the same effect, is always present in the sex organs and liver of Japanese puffer fish. Hence in Japan...
Nevertheless, Roche complied with the order, reducing U.K. prices again to a level even further below what it charges in other European countries or the U.S. The average retail price for 100 two-milligram capsules of Valium in Britain has fallen from around $3 in 1970 to about 75?-far less than the U.S. price, which runs from $6.50 to more than $11. Roche is now underselling its British competitors-who must also pay royalties to Roche...
...contraceptive effect could be produced by injections of 10 milligrams of aspirin or one-half milligram of indomethacin per rat for two days. These dosages are approximately equivalent to one and one-half times the maximum prescribed human dosage...
...Pauling says, partly because the drug companies cannot make enough money out of it and partly because doctors generally prescribe doses just large enough to prevent scurvy. In a paperback, Vitamin C and the Common Cold (W.H. Freeman & Co.; $1.95), Pauling recommends a daily 250-to-10,000 milligrams to keep colds from being caught, plus a crash dosage of 500-milligram tablets to kill them once they're started. Initial response to his finding was a run on ascorbic acid and much medical skepticism about Pauling's paucity of clinical data...