Word: mirrored
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Dates: during 1990-1999
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Unfortunately, there was a rather dramatic and unpleasant side effect. Like many organic molecules, fenfluramine comes in both a left-handed and a right-handed version. The molecules are like a pair of gloves, with identical composition and structure except that they are mirror images of each other. That gives them different chemical properties. In this case, the right-handed molecule, dexfenfluramine, was an appetite suppressant. But the left-handed version, levofenfluramine, made people uncontrollably drowsy. And Servier didn't have a commercially viable way to separate...
Meanwhile, Servier had finally figured out how to produce pure dexfenfluramine, without its mirror-image molecule. This was a potentially profitable discovery, since the patent on fenfluramine was about to run out, and the new formulation could be considered a novel, patentable drug. Servier approached Wurtman in the late 1970s with a proposal that he purchase the U.S. rights to dexfenfluramine. Wurtman tested the drug, found it was indeed effective and agreed. The actual purchaser would be Interneuron Pharmaceuticals, a company co-founded by Wurtman to market discoveries by M.I.T. scientists. Interneuron subsequently licensed the drug to Wyeth-Ayerst...
...national family picnic. Which is why on the first day, politicians were banished from sight. Actor Christopher Reeve barely mentioned Clinton in his speech, and when he talked about government, it was to describe it as the benign paternalistic arm ready to embrace America's civic life as a mirror of the homes baby boomers grew up in. Sarah Brady, the gun-control advocate, brought her wheelchair-bound husband onstage to deliver another above-the-fray message: Guns kill kids too. And of course Hillary Rodham Clinton returned to center stage with a coolly effective defense of her own child...
...beau, the twice-divorced Brolin is pretty low profile (remember Andre Agassi, Don Johnson, Peter Jennings and that guy who guest-stars on Friends, Elliott Gould?). It's probably only coincidence that this news broke just weeks before the arrival of Streisand's latest producing, directing, starring effort, The Mirror Has Two Faces...
...whom Pearl Jam frontman Eddie Vedder worked on the sound track to the film Dead Man Walking. Other songs are even more derivative. The countrified garage rocker Smile sounds like a Neil Young tune, right down to the harmonica solo (Pearl Jam worked with Young on his 1995 album, Mirror Ball); it's pleasant enough, but it lacks the ornery soul of the genuine article. Let's hope this is just a brief detour and that the next time out, Pearl Jam will find its way back to the gutsy inventiveness that deservedly made it the most popular band...