Word: misshapen
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...bathtub, and who relies on charm to get away with it. He used it on Saturday Night Live as young Simon, of course, and as basement TV host Wayne Campbell, and once or twice as Linda Richman. Austin Powers occasionally flashed that someone-stop-me grin through his misshapen English teeth. (Dieter the German performance artist and Shrek, not so much.) The Cat in the Hat was nothing but irritating-ingratiating impishness. And for the longest time - it's nearly two decades since he joined SNL - when Myers smiled, audiences smiled back. They were his co-conspirators in preadolescent aggression...
...Hara is perfect as an overbearing mom. Another actor, Simon Woods, pops off the screen as Edward, an utterly repulsive upper-class twit. Ricci does a terrific job looking cute—in fact, too cute. First-time director Mark Palansky played it safe with the nose: instead of misshapen, Penelope looks lovable. This makes scenes of would-be suitors jumping out the window and Edward’s tales of a horrendous pig-woman with dripping fangs hilariously implausible. While Penelope is not high-film, it’s a charming modern-day fairy tale. The moral...
...time and matter is messed up, but remains basically good, and God will eventually sort it out and put it right again. Belief in that goodness is absolutely essential to Christianity, both theologically and morally. But Greek-speaking Christians influenced by Plato saw our cosmos as shabby and misshapen and full of lies, and the idea was not to make it right, but to escape it and leave behind our material bodies. The church at its best has always come back toward the Hebrew view, but there have been times when the Greek view was very influential...
...Neil Cashman thought he had the answer. The University of Toronto scientist had spent his career trying to sift out the misshapen clumps of proteins thought to cause neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) that hid in a sandbox of normal proteins. In 2002 he finally succeeded, using a chemical agent to alter normal proteins but not so-called aggregated misfolded ones, leaving the clumps easier to detect. It would become the formula for a diagnostic kit usable by blood banks everywhere...
Corralling clumps of misshapen protein could open the way not just to diagnosis but also to treatment. In August, Amorfix partnered with Biogen Idec of Cambridge, Mass., to pursue treatment for ALS, or Lou Gehrig's disease, with the goal of blocking the protein from misfolding in the first place. "It's just the most awful disease, and the most challenging," says Cashman, who runs an ALS clinic in Vancouver, where he is research chairman of neurology at the University of British Columbia's department of medicine. "It may sound trite, but I want to make a difference, and this...