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SU2C is not the only independent group shaking things up. The Multiple Myeloma Research Foundation used a pay-for-results funding model that has more to do with Silicon Valley than Big Pharma to support research that in four years got four new treatments to patients--Thalomid, Velcade, Revlimid and Doxil. That's about six years faster than the decade it usually takes for such drug development and rollout. Multiple myeloma is a rare cancer of the bone marrow that sickens about 20,000 Americans each year--precisely the uncommon form of the disease that often falls into the research...
...MMRF made sure it got the most from its grant dollars by adopting an enforced-collaboration model in 2004, linking work at four cancer centers into a consortium managed by PricewaterhouseCoopers and providing them all with patients, tissue samples and a set of targets and goals. "The odds of a cure coming from one center are nil," Giusti says. "You need a mutual fund to fight cancer." From not having a single drug in the pipeline, the MMRF now has 30, half of them in clinical trials. The average lifespan of a multiple-myeloma patient has been extended by three...
...MMRF model works for a single, specialized cancer, it's not clear that a group like Stand Up to Cancer--which is casting a far wider research net--will show the same results. But clinicians say it's worth trying. "There needs to be a mechanism whereby we can bring groups of people together from different institutions in one group," says DuBois, who is part of SU2C's scientific panel. At the same time, there is hope that the 20% of grants SU2C is setting aside for outside-the-box research will yield something semimiraculous...
...debuted in 1985, U.S. soldiers called them "jeeps on steroids." More squat than sporty but superbly versatile, they served as troop carriers, command centers and ambulances. America got its first good look at them six years later during Desert Storm and liked what it saw enough that a civilian model appeared soon after. (Arnold Schwarzenegger was among the first to own one, more than a decade before he became governor of California and a champion of emissions standards.) By the mid-1990s, the Hummer's gleaming chrome grille and 14-m.p.g. (17 L/100 km) fuel consumption epitomized American extravagance. General...
Just four years ago, Harvard and MIT launched a decade-long experiment to test an innovative organizational model for scientific discovery. Today, the results...