Word: modelers
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...monkeys but failed miserably in human trials when it appeared to increase the rate of HIV transmission in study participants. "In the end," says Wayne Koff, senior vice president of research and development at the International AIDS Vaccine Initiative (IAVI), "you can only extrapolate so much from a monkey model...
VaxDesign's model may soften, if not sidestep, such devastating setbacks by allowing researchers to road test a vaccine in human immune systems earlier than ever before. In essence, the constructs act as "clinical trials in a test tube." When an experimental vaccine enters the tissue constructs, the simulated immune system will sound the alarm, just as it would inside a human. Then, it does what an immune system does best - whips up antibodies. If the vaccine is successful, the antibodies will wipe out the targeted disease the next time it shows up. Best yet, researchers can test hundreds...
...their sport. For this year's championship, each of the leading teams has spent around $300 million on building and fine-tuning its cars. Behind the drivers is a network of boffins - engineers, mechanics, wind-tunnel experts - charged with analyzing the performance of every system of last year's model with the goal of making the new one faster. Inevitably, the high stakes have led to skulduggery. The sport's governing body, the Paris-based International Automobile Federation (FIA), last year fined McLaren a record $100 million for possessing 800 pages of confidential technical data about the cars of arch...
...brilliant visionary and a genuinely compassionate human being, but he runs the danger of being trapped by his past," says Jeffrey Sonnenfeld, a professor at the Yale School of Management who has extensively studied CEOs. "Entrepreneurs sometimes don't grow with the business. You shouldn't pretend the model can't keep evolving." Schultz is fond of saying that the current energy and optimism reminds him of the early days, when Starbucks was "fighting for survival." It is a nostalgic way to look at things, and that, says Sonnenfeld, is a big problem...
...problem is revenue and an inefficient business model - and gripes that the Americans aren't competing on a level playing field. For one, the Japanese teams have not been run as profit-making entities; instead they traditionally operate as advertising vehicles for parent companies. The NPB's annual revenue is estimated to be only slightly over $1 billion, one sixth of what the U.S. draws. The salary gap between what the best players make in each country is equally large. The NPB has no integrated system of selling media or merchandising rights...