Word: mold
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Dates: during 1990-1999
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...subconscious. Even before landing, the truth can be distorted in the minds of the flight crew. In the case of the Italian accident, this self-denial was taken all the way from the bloodied ski slopes of Cavalese to the court-martial room in North Carolina. A.J. CRAIG Mold, Wales...
When he returned, he noticed a clear halo surrounding the yellow-green growth of a mold that had accidentally contaminated the plate. Unknown to him, a spore of a rare variant called Penicillium notatum had drifted in from a mycology lab one floor below. Luck would have it that Fleming had decided not to store his culture in a warm incubator, and that London was then hit by a cold spell, giving the mold a chance to grow. Later, as the temperature rose, the Staphylococcus bacteria grew like a lawn, covering the entire plate--except for the area surrounding...
...discovery that would change the course of history. The active ingredient in that mold, which Fleming named penicillin, turned out to be an infection-fighting agent of enormous potency. When it was finally recognized for what it was--the most efficacious life-saving drug in the world--penicillin would alter forever the treatment of bacterial infections. By the middle of the century, Fleming's discovery had spawned a huge pharmaceutical industry, churning out synthetic penicillins that would conquer some of mankind's most ancient scourges, including syphilis, gangrene and tuberculosis...
...Fleming had abandoned his work on penicillin. He would have no further role in the subsequent development of this or any other antibiotic, aside from happily providing other researchers with samples of his mold. It is said that he lacked both the chemical expertise to purify penicillin and the conviction that drugs could cure serious infections. However, he did safeguard his unusual strain of Penicillium notatum for posterity. The baton of antibiotic development was passed to others...
...specimen of Fleming's mold made its way into the hands of a team of scientists at Oxford University led by Howard Florey, an Australian-born physiologist. This team had technical talent, especially in a chemist named Ernst Boris Chain, who had fled Nazi Germany. Armed with funding from the Rockefeller Foundation, these scientists made it their objective to identify and isolate substances from molds that could kill bacteria. The mission was inspired by the earlier work of Gerhard Domagk, who in 1935 showed that the injection of a simple compound, Prontosil, cured systemic streptococcal infections. This breakthrough demonstrated that...