Word: molecular
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...Amos has been an inspiration, mentor and career counselor for young scientists and physicians-in-training for decades.” John J. Mekalanos, chair of the Department of Microbiology and Molecular Genetics at Harvard Medical School, said in an e-mail...
...Amos] has been and continues to be the consummate teacher: available, approachable, knowledgeable and wise,” Mekalanos said in the e-mail. “Members of the Department of Microbiology and Molecular Genetics are forever grateful that we can say that Harold Amos has been our advisor, colleague, teacher and friend...
...wasn't supposed to be this way. When researchers published their first highly detailed analysis of the structure of a human rhinovirus back in 1985, it was easy to imagine that a cure for the common cold might soon be available. After all, once scientists discovered which molecular footholds rhinoviruses use to latch onto and infect human cells, it should not have been that hard to develop a drug that would block the linkage and cure a cold before it got started. Or so the thinking went. Unfortunately, the logistics, from both a biological and a business point of view...
...something. That's a tall order but not impossible. In the mid-1990s the German drug company Boehringer-Ingelheim developed an antiviral molecule, dubbed BIRR 4, that proved in clinical trials to significantly shorten most colds triggered by rhinoviruses and lessen their severity. The product worked by mimicking those molecular footholds used by rhinoviruses to gain entry into human cells. Spraying the nasal passages every few hours on the first day of a cold essentially fooled the virus into leaving the cells alone...
Harvard scientists have also felt the pressure to avoid bumping up against the new ethos of secrecy and censorship. Presley Professor of Microbiology and Molecular Genetics R. John Collier is one of the nation’s foremost anthrax researchers. He worked on anthrax for years before white powder in the mail became a national obsession. New federal laws regulating research on things such as anthrax led Collier to destroy his only samples of anthrax to “avoid attracting terrorists and more of the press than I wanted,” he told The New York Times...