Word: molecular
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Over the next several years, researchers can be expected to bring into increasingly sharp focus the enormously complicated molecular pathway of which beta amyloid and tau are just the most visible signposts, and in so doing they are likely to reveal a raft of new opportunities for therapeutic intervention. For example, a change in shape appears to be what makes tau go bad. Last year Davies and Harvard's Dr. Kun Ping Lu announced that they had found an enzyme that seemed to restore tau to its proper configuration...
...finding how the four letters of the DNA alphabet (A, T, G and C) spell out the linear sequences of amino acids in the synthesis of proteins, the main actors in the drama of cellular life. As it turns out, the essence of the genetic code and of the molecular machinery that reads it was solidly established by 1966, only 13 years after Francis Crick and I discovered the double helix...
Congress accepted this message much faster than many of my fellow molecular biologists, soon appropriating moneys that let the genome project start with a bang. In October 1988, I went to Washington to direct the National Institutes of Health's major role in the effort. From the start, I worked to ensure that the project was an international one, supported by all the major countries of the developed world. That way no one nation or private body would be perceived as controlling the human genome. We also wanted all the data placed on the Internet so that they would...
...impossible to overstate the significance of this achievement. Armed with the genetic code, scientists can now start teasing out the secrets of human health and disease at the molecular level--secrets that will lead at the very least to a revolution in diagnosing and treating everything from Alzheimer's to heart disease to cancer, and more. In a matter of decades, the world of medicine will be utterly transformed, and history books will mark this week as the ceremonial start of the genomic...
...surf. But he had smarts. As a draft-eligible nonstudent, he says, he got the highest score of 35,000 recruits on a Navy intelligence test. Trained as a hospital corpsman, he saw North Vietnam's devastating Tet offensive in 1968. Says his wife Claire Fraser, a prominent molecular biologist: "Vietnam changed him. It impressed on him the idea that time is precious, that you have to make every single minute of every single day count...