Word: molecular
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...some of them doing work that is more advanced than Folkman's. But it's not the only field with potential. Just as exciting, say many researchers, is the revolution in cancer treatments made possible by what they've learned about how genes and cancer cells work at the molecular level, the fruits of which are already being delivered to human patients (see following story...
...Folkman's lab wanted anything to do with it. Finally one of them, Dr. Michael O'Reilly, agreed to take on the project. Together he and Folkman eventually determined that various segments of a naturally occurring protein called plasminogen seemed to do the trick. They called the collection of molecular fragments angiostatin and found that each version of the compound differed slightly in its ability to stop a tumor from growing...
...matter what its configuration, angiostatin could not make a mouse tumor disappear. Not, that is, until Folkman and O'Reilly added to the mix a second molecular fragment, which they called endostatin, from yet another naturally occurring protein. Together, the two compounds destroyed a range of tumors in mice. The results were startling enough that they merited testing in people--which is exactly what Pluda, at the National Cancer Institute, intends to do. How fast those studies can begin depends on how much angiostatin and endostatin EntreMed and its business partner, Bristol-Myers Squibb, can produce and whether they...
...factor receptors blocked by the new drugs play a role in normal cell division as well as in cancer. So disrupting them could cause harm. "Whether the therapy is going to be a major advance, a modest improvement or a disappointment is not clear," says Dr. J. Michael Bishop, molecular biologist at the University of California, San Francisco, who shared a 1989 Nobel Prize with Dr. Harold Varmus for their pioneering work on oncogenes. But Bishop is impressed that the field is moving so swiftly, and most researchers are convinced that they are at least on the right track. Says...
HHMI currently employs 15 investigators inCambridge, including Assistant Professor ofMolecular and Cellular Biology Catherine Dulac,Professor of Biological Chemistry and MolecularPharmacology Stephen C. Harrison '63, Professor ofBiochemistry and Molecular Biology Douglas A.Melton, Professor of Chemistry Stuart L. Schreiberand Professor of Biochemistry and Biophysics DonC. Wiley at Harvard...