Word: molecular
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...that are essential to the original mutation and attack that,” Harlow said. Fisher said he is looking forward to working with Harlow and having a “cross-campus” collaboration between Mass. General and Harvard’s Department of Biological Chemistry and Molecular Pharmacology. According to Professor Andrew B. Lassar, a member of the Department of Biological Chemistry and Molecular Pharmacology, Harlow’s “work will not only deepen our understanding of the signaling pathways that are necessary for cancers to grow but hopefully will lead to therapeutic interventions...
...bead on a much smaller region, closer to the soles of the viral bobble head's feet, where the virus fuses to the cell it infects. These regions mutate less rapidly, and in fact, in the recent study in mice, published in the current issue of Nature Structural & Molecular Biology, they did not mutate at all. "If we use this approach judiciously, we should be able to keep this pocket conserved and not develop drug resistance to it," says Dr. Wayne Marasco of the Dana Farber Cancer Institute, a co-author of the paper. "The exciting part is that this...
Professor Jeff W. Lichtman and his team painstakingly craft their colorful masterpieces—but their paintbrush is the genome, and their canvass the brain. Lichtman and his colleague Joshua R. Sanes, both molecular and cellular biology professors at Harvard, are mapping neurons with a pioneering method, dubbed “brainbow” for its psychedelic appearance. Already, the technique—recently honored with a Nobel Prize in chemistry—is shedding light on the development of the human mind, and how disorders such as Alzheimer’s and even anxiety alter the brain...
...spread just by chance. And a lot of our genome is not made up of protein-coding genes. In fact, 98.8% of it is not. Some of that 98.8% consists of "pseudogenes" - genes that once encoded proteins but no longer can because of a crippling mutation. They are the molecular equivalent of a vestigial tail, allowing us to see evolution's track...
...like a genetic cookbook, using four molecular "letters" to spell out recipes for everything from hormones to heart valves. Biologists today are reading the 3.5 billion letters in the human genome as well as the DNA from thousands of other species, and they've amassed vast databases of genetic information that they can rummage through to learn about how life evolved...