Word: molecular
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...have to work differently from the ones used to treat fragile X syndrome because the biology of the disease is different too. In fragile X, the key gene is silent; in FXTAS patients, it's too active. "The gene produces up to 10 times more message than normal," explains molecular biologist Paul Hagerman of the University of California at Davis, who together with wife Randi has received an NIH grant to study the disorder. Over time, messenger RNA--the substance that transcribes genes into proteins--accumulates in the nuclei of brain cells, eventually poisoning them...
While scientists work out the molecular pathways that may someday cure FXS and FXTAS, clinicians at more than a dozen centers around the country are devising ways to improve life for affected families. Children with FXS are referred to programs that offer language services, occupational therapy and special education. Randi Hagerman is a believer in drugs to treat anxiety and hyperactivity. For patients with FXTAS, she prescribes exercise and medications already used to treat Parkinson's and Alzheimer's disease...
...molecular and cellular biology, students must submit a proposal to the department over the summer before getting the formal go-ahead. In history and literature, a committee looks over each student’s proposal and bibliography early in the year, providing written comments to the adviser. The history department, which had eight Hoopes Prize winners this year, requires its students to enroll in History 99, a small class that meets every two to three weeks. “I would be willing to guess we’re the most structured of any of the departments in the College...
...neurons in the brain - but doctors don't know what pushes normal glial cells to become cancerous in the first place. "We know very little about the biology of malignant glioma," says Dr. Azad Bonni, a professor of pathology at Harvard Medical School who is investigating some of the molecular explanations behind the disease...
...presenting teaching fellow Michael L. Dougan one of the Joseph R. Levenson Memorial Teaching Awards last night, Ashish Agrawal ’08, told a story of Dougan’s dedication to his students: two days before his wife’s due date, the molecular and cellular biology TF held a review session. Students and faculty gathered last night to hear stories of dedication like this one and celebrate exemplary teaching at Harvard by honoring the nominees for the 25th annual Levenson Prize. The recipients of the three awards—one senior faculty member, one junior faculty...